Since the completion of the first human genome sequence and the advent of next generation
sequencing technologies, remarkable progress has been made in understanding the …

Epigenetic modifications characterized by DNA methylation, histone modifications, and
chromatin remodeling are important regulators in a number of biological processes …

Multicellular eukaryotic genomes show enormous differences in size. A substantial part of
this variation is due to the presence of transposable elements (TEs). They contribute …

DNA methylation of promoter sequences is a repressive epigenetic mark that down-
regulates gene expression. However, DNA methylation is more prevalent within gene …

MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …

Methylation of DNA at the dinucleotide CpG is essential for mammalian development and is
correlated with stable transcriptional silencing 1, 2, 3. This transcriptional silencing has …

Background: The regulation of DNA methylation is required for differential expression of
imprinted genes during vertebrate development. Earlier studies that monitored the activity of …

В монографии изложены современные представления об этиологии и патогенезе
хромосомных болезней. Рассмотрены основные стадии гаметогенеза и эмбриогенеза …

DNA methylation is an epigenetic process involved in embryonic development,
differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in …

The development of novel therapeutic approaches is necessary to manage gastrointestinal
cancers (GICs). Considering the effective molecular mechanisms involved in tumor growth …