Autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney
disease are the best known of a large family of inherited diseases characterized by the …

An increased understanding of the genetic, molecular and cellular mechanisms responsible
for the development of polycystic kidney disease has laid out the foundation for the …

Autosomal dominant polycystic kidney disease, caused by mutations in the PKD1 gene, is
characterized by progressive deterioration of kidney function due to the formation of …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common human
monogenic genetic disorder and is characterized by progressive bilateral renal cysts and the …

Various cellular insults and injury to renal epithelial cells stimulate repair mechanisms to
adapt and restore the organ homeostasis. Renal tubular epithelial cells are endowed with …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic
disease predominantly caused by alteration or dysregulation of the PKD1 gene, which …

Abstract Mutations in polycystin-1 (PC1) and polycystin-2 (PC2) result in a commonly
occurring genetic disorder, called Autosomal Dominant Polycystic Kidney Disease (ADPKD) …

Autosomal dominant polycystic kidney disease (ADPKD) largely results from mutations in
the PKD1 gene leading to hyperproliferation of renal tubular epithelial cells and consequent …

Ciliary dysfunction has emerged as a common factor underlying the pathogenesis of both
syndromic and isolated kidney cystic disease, an observation that has contributed to the …

Abstract Mutations in PKD1 (85%) or PKD2 (15%) account for almost all cases of autosomal
dominant polycystic kidney disease (ADPKD). The ADPKD proteins, termed as polycystin-1 …