Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

Somaclonal variation arises in plants and animals when differentiated somatic cells are
induced into a pluripotent state, but the resulting clones differ from each other and from their …

We have developed a new generation of genome-wide DNA methylation BeadChip which
allows high-throughput methylation profiling of the human genome. The new high density …

DNA methylation is the most widely studied epigenetic mark and is known to be essential to
normal development and frequently disrupted in disease. The Illumina …

Abstract In the early 1950's,'host-controlled variation in bacterial viruses' was reported as a
non-hereditary phenomenon: one cycle of viral growth on certain bacterial hosts affected the …

Aims: Bisulfite sequence analysis of individual CpG sites within genomic DNA is a powerful
approach for methylation analysis in the genome. The major limitation of bisulfite-based …

DNA methylation is an indispensible epigenetic modification required for regulating the
expression of mammalian genomes. Immunoprecipitation-based methods for DNA …

This study was originally conceived to test in a rigorous way the specificity of three major
approaches to high-throughput array-based DNA methylation analysis:(1) MeDIP, or …

OBJECTIVE—Low birth weight (LBW) is associated with increased risk of obesity, diabetes,
and cardiovascular disease during adult life. Moreover, this programmed disease risk can …