Many clinical trials using gene therapy have shown significant therapeutic benefits and
exceptional safety records. Increasing evidence is verifying the long sought-after promise …

Genome-editing technology has enabled scientists to make changes in model organisms'
DNA at the genomic level to get biotechnologically important products from them. Most …

The term “CRISPR” has gained a lot of attention recently as a result of a debate among
scientists about the possibility of genetically modifying the human germ line and the ethical …

Balancing therapeutic prospects brought by scientific advances with regulation to address
highly contested socioethical issues is the ultimate challenge in dealing with disruptive …

BACKGROUND With the recent development of CRISPR (clustered regularly interspaced
short palindromic repeats)/Cas9 genome editing technology, the possibility to genetically …

STUDY QUESTION What are the reasons for or against the future clinical application of
germline genome modification (GGM)? SUMMARY ANSWER A total of 169 reasons were …

Technological developments in gene editing raise high expectations for clinical applications,
including editing of the germline. The European Society of Human Reproduction and …

Psychotic disorders and eating disorders sometimes occur in the same person, and
sometimes, but not always, at the same time. This can cause diagnostic confusion and …

Although germline editing has been the subject of debate ever since the 1980s, it tended to
be based rather on speculative assumptions until April 2015, when CRISPR/Cas9 …

Novel cellular immunotherapy with engineered T cells has improved cancer treatment and
established therapeutic promises to prevent tumor formation in clinical studies. Due to …