Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic,
epigenetic, and environmental factors. Recent advance in genomics and epigenetics have …

As an important epigenetic modification, DNA methylation is involved in many biological
processes such as animal cell differentiation, embryonic development, genomic imprinting …

During embryo development, DNA methylation is established by DNMT3A/3B and
subsequently maintained by DNMT1. While much research has been done in this field, the …

Abstract N 4-methylcytosine (4mC) is a DNA modification involving the addition of a methyl
group to the fourth nitrogen atom of the cytosine base. This modification may influence gene …

Spontaneous abortion is a pregnancy complication characterized by complex and
multifactorial etiology. About 5% of childbearing women are globally affected by early …

Background During early mammalian development, DNA methylation undergoes two waves
of reprogramming, enabling transitions between somatic cells, oocyte and embryo. The first …

While exercise (EX) during pregnancy is beneficial for both mother and child, little is known
about the mechanisms by which maternal exercise mediates changes in utero. Six-week-old …

TEAD4 is a transcription factor that plays a crucial role in the Hippo pathway by regulating
the expression of genes related to proliferation and apoptosis. It is also involved in the …

The placenta connecting the fetus to the maternal uterus provides material exchange and an
immune-tolerant environment for the embryo in all eutherian mammals (Shao et al., 2022) …

Background There exists a critical transition or tipping point during the complex biological
process. Such critical transition is usually accompanied by the catastrophic consequences …