Zygotic genome activation in vertebrates
The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …
Chromatin control of developmental dynamics and plasticity
M Perino, GJC Veenstra - Developmental cell, 2016 - cell.com
Chromatin structure is intimately connected with gene expression and cell identity. Here we
review recent advances in the field and discuss how establishment of cell identity during …
review recent advances in the field and discuss how establishment of cell identity during …
Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos
The regulation of transcription requires the coordination of numerous activities on DNA, yet
how transcription factors mediate these activities remains poorly understood. Here, we use …
how transcription factors mediate these activities remains poorly understood. Here, we use …
Brd4 and P300 confer transcriptional competency during zygotic genome activation
The awakening of the genome after fertilization is a cornerstone of animal development.
However, the mechanisms that activate the silent genome after fertilization are poorly …
However, the mechanisms that activate the silent genome after fertilization are poorly …
Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis
SA Blythe, EF Wieschaus - Elife, 2016 - elifesciences.org
During embryogenesis, the initial chromatin state is established during a period of rapid
proliferative activity. We have measured with 3-min time resolution how heritable patterns of …
proliferative activity. We have measured with 3-min time resolution how heritable patterns of …
mRNA poly (A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos
SW Eichhorn, AO Subtelny, I Kronja, JC Kwasnieski… - Elife, 2016 - elifesciences.org
Because maturing oocytes and early embryos lack appreciable transcription,
posttranscriptional regulatory processes control their development. To better understand this …
posttranscriptional regulatory processes control their development. To better understand this …
Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos
Upon fertilization, the genome of animal embryos remains transcriptionally inactive until the
maternal-to-zygotic transition. At this time, the embryo takes control of its development and …
maternal-to-zygotic transition. At this time, the embryo takes control of its development and …
CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity
Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is
known about the role of chromatin factors during this process. Here, we used an in vivo RNA …
known about the role of chromatin factors during this process. Here, we used an in vivo RNA …
Continued activity of the pioneer factor Zelda is required to drive zygotic genome activation
Reprogramming cell fate during the first stages of embryogenesis requires that
transcriptional activators gain access to the genome and remodel the zygotic transcriptome …
transcriptional activators gain access to the genome and remodel the zygotic transcriptome …
The Drosophila pioneer factor Zelda modulates the nuclear microenvironment of a dorsal target enhancer to potentiate transcriptional output
Connecting the developmental patterning of tissues to the mechanistic control of RNA
polymerase II remains a long-term goal of developmental biology. Many key elements have …
polymerase II remains a long-term goal of developmental biology. Many key elements have …