Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven
metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA …

The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer
progression remain to be fully understood. While altered glucose metabolism in CAFs could …

Recently, long noncoding RNAs (lncRNAs) were found to be dysregulated in a variety of
tumors. However, it remains unknown how and through what molecular mechanisms the …

DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …

Recent studies have revealed extensive genetic and non-genetic variation across different
geographical regions of a tumor or throughout different stages of tumor progression, which is …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …

Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …