Advances in hypoxia-inducible factor biology
H Choudhry, AL Harris - Cell metabolism, 2018 - cell.com
Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …
Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven
metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA …
metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA …
Epigenetic reprogramming of cancer-associated fibroblasts deregulates glucose metabolism and facilitates progression of breast cancer
LM Becker, JT O'Connell, AP Vo, MP Cain, D Tampe… - Cell reports, 2020 - cell.com
The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer
progression remain to be fully understood. While altered glucose metabolism in CAFs could …
progression remain to be fully understood. While altered glucose metabolism in CAFs could …
[HTML][HTML] Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis
F Yang, X Huo, S Yuan, L Zhang, W Zhou, F Wang… - Molecular cell, 2013 - cell.com
Recently, long noncoding RNAs (lncRNAs) were found to be dysregulated in a variety of
tumors. However, it remains unknown how and through what molecular mechanisms the …
tumors. However, it remains unknown how and through what molecular mechanisms the …
Cigarette smoking and DNA methylation
KWK Lee, Z Pausova - Frontiers in genetics, 2013 - frontiersin.org
DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …
expression in the contexts of normal traits or diseases. It is highly dynamic during early …
Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment
X Sun, Q Yu - Acta Pharmacologica Sinica, 2015 - nature.com
Recent studies have revealed extensive genetic and non-genetic variation across different
geographical regions of a tumor or throughout different stages of tumor progression, which is …
geographical regions of a tumor or throughout different stages of tumor progression, which is …
S-adenosylmethionine in Liver Health, Injury, and Cancer
SC Lu, JM Mato - Physiological reviews, 2012 - journals.physiology.org
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …
methyl donor synthesized in all mammalian cells but most abundantly in the liver …
'Reverse Warburg effect'of cancer‑associated fibroblasts
L Liang, W Li, X Li, X Jin, Q Liao… - … Journal of Oncology, 2022 - spandidos-publications.com
Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …
Role of hypoxia inducible factor-1 in cancer stem cells
Q Zhang, Z Han, Y Zhu, J Chen… - Molecular Medicine …, 2021 - spandidos-publications.com
Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence,
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …
metastasis, and chemo‑, radio‑and immuno‑resistance. Understanding the mechanism of …
Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives
FI Milagro, ML Mansego, C De Miguel… - Molecular aspects of …, 2013 - Elsevier
Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …