Physical exercise induces adaptive changes leading to a muscle phenotype with enhanced
performance. We first investigated whether genetic polymorphisms altering enzymes …

Gene silencing resulting from aberrant DNA methylation can lead to tumorigenesis.
Therefore, drugs that inhibit or interfere with DNA methylation have been used to reactivate …

Prostate cancer is the most common cancer among men. The prospective discrimination of
aggressive and clinically insignificant tumors still poses a significant and, as yet, unsolved …

Hypermethylation of the paired-like homeodomain transcription factor 2 (PITX2) gene is a
strong predictor of the risk of biochemical recurrence in patients with prostate cancer (PCa) …

Myogenesis is a multistep process, in which myoblasts withdraw from the cell cycle, cease to
divide, elongate and fuse to form multinucleated myotubes. Cell cycle transition is controlled …

Objective To investigate whether in utero opioid exposure, which has been linked to adverse
neurodevelopmental and social outcomes, is associated with altered DNA methylation of …

The inheritance of DNA methylation patterns is a popular theory to explain the influence of
parental genetic and environmental factors on the phenotype of their offspring but few …

DNA methylation plays a critical role in the regulation of gene expression. Global DNA
methylation changes occur in carcinogenesis as well as early embryonic development …

DNA methylation patterns are inherited from parents and are imperative for proper
embryonic development; however, alterations in these patterns can compromise fertilization …

James Wilson originally proposed a set of “Principles of Teratology” in 1959, the year before
he helped to found the Teratology Society. By 1977, when these Principles were presented …