Nanomaterials for theranostics: recent advances and future challenges
In 2004, the US Food and Drug Administration (FDA) released an important report entitled
“Innovation/Stagnation: Challenge and Opportunity on the Critical Path to New Medical …
“Innovation/Stagnation: Challenge and Opportunity on the Critical Path to New Medical …
[PDF][PDF] Dissecting the heterogeneity of triple-negative breast cancer
O Metzger-Filho, A Tutt, E De Azambuja… - Journal of clinical …, 2012 - researchgate.net
Triple-negative breast cancer (TNBC) accounts for 15% to 20% of breast cancers. It is a
heterogeneous disease, not only on the molecular level, but also on the pathologic and …
heterogeneous disease, not only on the molecular level, but also on the pathologic and …
[图书][B] Bioinorganic Chemistry--Inorganic Elements in the Chemistry of Life: An Introduction and Guide
W Kaim, B Schwederski, A Klein - 2013 - books.google.com
The field of Bioinorganic Chemistry has grown significantly in recent years; now one of the
major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life …
major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life …
Evolution of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic
DV Ferraris - Journal of medicinal chemistry, 2010 - ACS Publications
Poly (ADP-ribose) polymerase-1 (PARP-1a) has been an actively pursued drug discovery
target for almost 3 decades. Often referred to as the “guardian angel of DNA”, 1 this …
target for almost 3 decades. Often referred to as the “guardian angel of DNA”, 1 this …
DNA‐damage‐response‐targeting mitochondria‐activated multifunctional prodrug strategy for self‐defensive tumor therapy
We report a novel multifunctional construct, M1, designed explicitly to target the DNA
damage response in cancer cells. M1 contains both a floxuridine (FUDR) and protein …
damage response in cancer cells. M1 contains both a floxuridine (FUDR) and protein …
Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways
DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the
DNA repair pathways have been identified in several human cancers. Thus, compounds …
DNA repair pathways have been identified in several human cancers. Thus, compounds …
An insight into the therapeutic potential of quinazoline derivatives as anticancer agents
I Ahmad - MedChemComm, 2017 - pubs.rsc.org
Cancer is one of the major causes of worldwide human mortality. A wide range of cytotoxic
drugs are available on the market, and several compounds are in different phases of clinical …
drugs are available on the market, and several compounds are in different phases of clinical …
Multifunctional plasmonic shell–magnetic core nanoparticles for targeted diagnostics, isolation, and photothermal destruction of tumor cells
Cancer is the greatest challenge in human healthcare today. Cancer causes 7.6 million
deaths and economic losses of around 1 trillion dollars every year. Early diagnosis and …
deaths and economic losses of around 1 trillion dollars every year. Early diagnosis and …
Advances in enzyme-free nucleic acid amplification-based fluorescent biosensors for real-time imaging of DNA repair enzymes in living cells
To maintain the stability and integrity of cellular genomic DNA, DNA repair enzymes catalyze
the repair of DNA damage caused by exogenous and endogenous factors through various …
the repair of DNA damage caused by exogenous and endogenous factors through various …
Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering …
W Lu, SR Arumugam, D Senapati, AK Singh… - ACS …, 2010 - ACS Publications
Breast cancer is the most common cancer among women, and it is the second leading
cause of cancer deaths in women today. The key to the effective and ultimately successful …
cause of cancer deaths in women today. The key to the effective and ultimately successful …