Role of inflammatory mechanisms in major depressive disorder: from etiology to potential pharmacological targets
BR Kouba, L de Araujo Borba, P Borges de Souza… - Cells, 2024 - mdpi.com
The involvement of central and peripheral inflammation in the pathogenesis and prognosis
of major depressive disorder (MDD) has been demonstrated. The increase of pro …
of major depressive disorder (MDD) has been demonstrated. The increase of pro …
[HTML][HTML] Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders
C Toader, N Dobrin, D Costea, LA Glavan… - International journal of …, 2024 - mdpi.com
Psychiatric disorders represent a primary source of disability worldwide, manifesting as
disturbances in individuals' cognitive processes, emotional regulation, and behavioral …
disturbances in individuals' cognitive processes, emotional regulation, and behavioral …
Astrocyte-specific inhibition of sigma-1 receptor leads to depressive-like behaviors in mice via activation of NF-κB-induced neuroinflammation
JY Wang, P Ren, LY Cui, JY Duan, HL Chen… - Brain, Behavior, and …, 2024 - Elsevier
Major depressive disorder (MDD) is a global health burden characterized by persistent low
mood, deprivation of pleasure, recurrent thoughts of death, and physical and cognitive …
mood, deprivation of pleasure, recurrent thoughts of death, and physical and cognitive …
[HTML][HTML] “Inflamed” depression: A review of the interactions between depression and inflammation and current anti-inflammatory strategies for depression
Y Yin, T Ju, D Zeng, F Duan, Y Zhu, J Liu, Y Li… - Pharmacological …, 2024 - Elsevier
Depression is a common mental disorder, the effective treatment of which remains a
challenging issue worldwide. The clinical pathogenesis of depression has been deeply …
challenging issue worldwide. The clinical pathogenesis of depression has been deeply …
TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin) induces depression-like phenotype
RA Debler, PL Gallegos, AC Ojeda, AM Perttula… - NeuroToxicology, 2024 - Elsevier
The etiology of major depressive disorder (MDD) remains poorly understood. Our previous
studies suggest a role for the aryl hydrocarbon receptor (AhR) in depression. 2, 3, 7, 8 …
studies suggest a role for the aryl hydrocarbon receptor (AhR) in depression. 2, 3, 7, 8 …
[HTML][HTML] Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ–TPH2 Axis
N Chen, X Xu, Y Guo, M Zhao, Y Li, T Zhou, X Zhang… - Research, 2024 - spj.science.org
Short-chain fatty acids (SCFAs) have been increasingly evidenced to be important bioactive
metabolites of the gut microbiota and transducers in controlling diverse psychiatric or …
metabolites of the gut microbiota and transducers in controlling diverse psychiatric or …
A comprehensive analysis of the differential expression in the hippocampus of depression induced by gut microbiota compared to traditional stress
X Chen, X Mo, Y Zhang, D He, R Xiao, Q Cheng… - Gene, 2024 - Elsevier
Depression, which is a disease of heterogeneous etiology, is characterized by high disability
and mortality rates. Gut microbiota are associated with the development of depression. To …
and mortality rates. Gut microbiota are associated with the development of depression. To …
[HTML][HTML] The relationship of peripheral blood cell inflammatory biomarkers and psychological stress in unmedicated major depressive disorder
Y Liu, C Li, H Ren, K Han, X Wang, S Zang… - Journal of Psychiatric …, 2024 - Elsevier
Background Recent research has explored the linkage between major depressive disorder
(MDD) and inflammation, especially via altered peripheral blood immune markers. However …
(MDD) and inflammation, especially via altered peripheral blood immune markers. However …
[HTML][HTML] Activation of pyramidal neurons in the infralimbic cortex alleviates LPS-induced depressive-like behavior in mice
PF Zhang, WY You, YJ Gao, XB Wu - Brain Research Bulletin, 2024 - Elsevier
The infralimbic (IL) cortex dysfunction has been implicated in major depressive disorder
(MDD), yet the precise cellular and molecular mechanisms remain poorly understood. In this …
(MDD), yet the precise cellular and molecular mechanisms remain poorly understood. In this …
[HTML][HTML] A pilot study of repeated suicide attempts in persons hospitalized for depression: The role of immune factors
F Dickerson, E Katsafanas, S Khan, A Origoni… - Journal of Affective …, 2024 - Elsevier
Background Individuals with major depressive disorder (MDD) hospitalized for a suicide
attempt are at high risk for a repeated suicide attempt. Previous studies have identified …
attempt are at high risk for a repeated suicide attempt. Previous studies have identified …