Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …

In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Almost half of the human genome is made up of transposable elements (TEs), and about 8%
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

To elucidate principles operating in native biological systems and to develop novel
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …

Neuroendocrine (NE) prostate cancer (NEPC) is a lethal subtype of castration-resistant
prostate cancer (PCa) arising either de novo or from transdifferentiated prostate …

Background Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal
disease. As the most common microvascular complication of diabetes, DKD is a thorny …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …