Methylated lysine 27 on histone H3 (H3K27me) marks repressed “facultative
heterochromatin,” including developmentally regulated genes in plants and animals. The …

The ability of a cell to dynamically switch its chromatin between different functional states
constitutes a key mechanism regulating gene expression. Histone mark “readers” display …

Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

The impact of transposable elements (TEs) on the evolution of the eukaryote genome has
been observed in a number of biological processes, such as the recruitment of the host's …

The perinatal period is a window of heightened plasticity that lays the groundwork for future
anatomic, physiologic, and behavioral outcomes. During this time, maternal diet plays a …

Colorectal cancer (CRC) is one of the most common malignancies and is a major cause of
cancer-related deaths worldwide. Thus, there is a clinical need to improve early detection of …

Fungal secondary metabolites are small molecules that exhibit diverse biological activities
exploited in medicine, industry and agriculture. Their biosynthesis is governed by co …

Epigenetic studies of both intragenerational and transgenerational epigenetic phenotypic
modifications have proliferated in the last few decades. However, the strong reductionist …

Epigenetics is the study of heritable mechanisms that can modify gene activity and
phenotype without modifying the genetic code. The basis for the concept of epigenetics …

Kabuki syndrome (KS) is caused by mutations in KMT2D, which is a histone
methyltransferase involved in methylation of H3K4, a histone marker associated with DNA …