[HTML][HTML] Diversity of fungal DNA methyltransferases and their association with DNA methylation patterns
DNA methyltransferases (DNMTs) are a group of proteins that catalyze DNA methylation by
transferring a methyl group to DNA. The genetic variation in DNMTs results in differential …
transferring a methyl group to DNA. The genetic variation in DNMTs results in differential …
[HTML][HTML] Epigenetics and early development
G Gopinathan, TGH Diekwisch - Journal of Developmental Biology, 2022 - mdpi.com
The epigenome controls all aspect of eukaryotic development as the packaging of DNA
greatly affects gene expression. Epigenetic changes are reversible and do not affect the …
greatly affects gene expression. Epigenetic changes are reversible and do not affect the …
[HTML][HTML] The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio)
The pyrethroid insecticide permethrin is widely used for agricultural and domestic purposes.
Previous data indicated that it acts as a developmental neurotoxicant and can induce …
Previous data indicated that it acts as a developmental neurotoxicant and can induce …
[HTML][HTML] GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML
While the majority of myelodysplasia and acute myeloid leukemia (MDS/AML) cases are
sporadic, rare familial predisposition syndromes have been delineated and now represent a …
sporadic, rare familial predisposition syndromes have been delineated and now represent a …
Genetics of schizophrenia: historical insights and prevailing evidence
Abstract Schizophrenia's (SZ's) heritability and familial transmission have been known for
several decades; however, despite the clear evidence for a genetic component, it has been …
several decades; however, despite the clear evidence for a genetic component, it has been …
DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients
E Dong, WB Ruzicka, DR Grayson, A Guidotti - Schizophrenia research, 2015 - Elsevier
The down regulation of glutamic acid decarboxylase67 (GAD1), reelin (RELN), and BDNF
expression in brain of schizophrenia (SZ) and bipolar (BP) disorder patients is associated …
expression in brain of schizophrenia (SZ) and bipolar (BP) disorder patients is associated …
Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state
G Velasco, G Grillo, N Touleimat, L Ferry… - Human molecular …, 2018 - academic.oup.com
Alterations of DNA methylation landscapes and machinery are a hallmark of many human
diseases. A prominent case is the ICF syndrome, a rare autosomal recessive immunological …
diseases. A prominent case is the ICF syndrome, a rare autosomal recessive immunological …
[PDF][PDF] Mendelian randomization analysis identifies CpG sites as putative mediators for genetic influences on cardiovascular disease risk
The extent to which genetic influences on cardiovascular disease risk are mediated by
changes in DNA methylation levels has not been systematically explored. We developed an …
changes in DNA methylation levels has not been systematically explored. We developed an …
ALS and FTD: an epigenetic perspective
VV Belzil, RB Katzman, L Petrucelli - Acta neuropathologica, 2016 - Springer
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two fatal
neurodegenerative diseases seen in comorbidity in up to 50% of cases. Despite tremendous …
neurodegenerative diseases seen in comorbidity in up to 50% of cases. Despite tremendous …
[HTML][HTML] Epigenetic modulation of stem cells in neurodevelopment: the role of methylation and acetylation
M Podobinska, I Szablowska-Gadomska… - Frontiers in cellular …, 2017 - frontiersin.org
The coordinated development of the nervous system requires fidelity in the expression of
specific genes determining the different neural cell phenotypes. Stem cell fate decisions …
specific genes determining the different neural cell phenotypes. Stem cell fate decisions …