5-methylcytosine (m5C) is an abundant RNA modification that's presence is reported in a
wide variety of RNA species, including cytoplasmic and mitochondrial ribosomal RNAs …

In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …

Summary DNA N 6-methyladenine (6mA) modification is commonly found in microbial
genomes and plays important functions in regulating numerous biological processes in …

The AlkB family of Fe (II)-and α-ketoglutarate-dependent dioxygenases is a class of
ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases …

DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …

DNA-editing enzymes perform chemical reactions on DNA nucleobases. These reactions
can change the genetic identity of the modified base or modulate gene expression. Interest …

Hypermethylation of CpG islands in the promoter regions is an important mechanism to
silence the expression of many important genes in cancer. The hypermethylation status is …

Highlights•Bacterial genomes contain C 5-methyl-cytosine, N 4-methyl-cytosine, and N 6-
methyl-adenine.•Base methylation controls DNA–protein interactions.•DNA methylation …

Epigenetic silenced alleles of the Arabidopsis SUPERMAN locus (the clark kent alleles) are
associated with dense hypermethylation at noncanonical cytosines (CpXpG and asymmetric …

DNA methylation has two essential roles in plants and animals—defending the genome
against transposons and regulating gene expression. Recent experiments in Arabidopsis …