The Dnmt2 enzymes show strong amino acid sequence similarity with eukaryotic and
prokaryotic DNA-(cytosine C5)-methyltransferases. Yet, Dnmt2 enzymes from several …

Epidemiological studies have shown that intake of tea catechins is associated with a lower
risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been …

Beyond its role in host defense, bacterial DNA methylation also plays important roles in the
regulation of gene expression, virulence and antibiotic resistance. Bacterial cells in a clonal …

▪ Abstract Recent structural and biochemical studies have begun to illuminate how cells
solve the problems of recognizing and removing damaged DNA bases. Bases damaged by …

RNA and DNA modifications occur in eukaryotes and prokaryotes, as well as in their viruses,
and serve a wide range of functions, from gene regulation to nucleic acid protection …

Enzymatic methylation of DNA plays important roles in both prokaryotes and eukaryotes.
Structural study of the Hhal DNA methyltransferase has provided considerable insight into …

DNA MTases (methyltransferases) catalyse the transfer of methyl groups to DNA from
AdoMet (S-adenosyl-l-methionine) producing AdoHcy (S-adenosyl-l-homocysteine) and …

DNA-protein cross-links (DPCs) present a formidable obstacle to cellular processes
because they are" superbulky" compared with the majority of chemical adducts. Elimination …

Methyltransferases (MTases) form a large family of enzymes that methylate a diverse set of
targets, ranging from the three major biopolymers to small molecules. Most of these MTases …

The refined crystal structures ofHhaI methyltransferase complexed with cognate
unmethylated or methylated DNA together withS-adenosyl-L-homocysteine, along with the …