The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

Abstract A strong genetic predisposition (60–80% of attributable risk) is present in
Alzheimer's disease (AD). In view of this major genetic component, identification of the …

Amyloid deposition and neurofibrillary degeneration in Alzheimer's disease specifically
affect discrete neuronal systems, but the underlying mechanisms that render some brain …

Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a
subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs …

Alzheimer's disease (AD) afflicts an estimated 20 million people worldwide and is the fourth-
leading cause of death in the developed world. The most common cause of dementia in …

Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction
and loss of synapses and neurons lead to cognitive impairment and death. Accumulation …

Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …

The amyloid precursor protein (APP) is linked to the genetics and pathogenesis of
Alzheimer's disease (AD). It is the parent protein of the β-amyloid (Aβ) peptide, the main …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is the most
common cause of dementia. Symptoms of AD include memory loss, disorientation, mood …