In recent years, oxaliplatin-based chemotherapy protocols, particularly oxaliplatin in
combination with infusional 5-fluorouracil/leucovorin (FOLFOX or FUFOX), have emerged as …

This review will discuss the key preclinical and clinical features of antifolates, from
methotrexate (MTX) to pemetrexed and beyond. Despite 50 years of study, definition of the …

目的前瞻性比较雷替曲塞或氟尿嘧啶/亚叶酸钙联合奥沙利铂治疗局部晚期或复发转移性结直肠
癌的有效性和安全性. 方法经病理组织学或细胞学确诊的局部晚期或复发转移性的结直肠癌患者 …

Abstract Purpose: Glutathione S-transferases (GST) are xenobiotic metabolizing enzymes
involved in the detoxification of a variety of chemotherapeutic drugs, including platinum …

Background New chemotherapy regimens for patients with colorectal cancer have improved
survival, but at the cost of clinical toxicity. Oxaliplatin, an agent used in first-line therapy for …

Fatigue is a subjective experience that affects everybody. In healthy individuals, it can be
considered a physiological response to physical or psychological stress. In people with …

Inhibitors of thymidylate synthase (TS) play an essential role in the pharmacological
management of several tumors. Two antifolates, Raltitrexed and Pemetrexed, are licensed …

Oxaliplatin (Eloxatin™) is the only platinum compound to show clinical activity in colorectal
cancer. The efficacy of a combination of oxaliplatin with various schedules of fluorouracil (5 …

Aims To evaluate the efficiency and safety profile of raltitrexed-based chemotherapy in the
treatment of advanced colorectal cancer. Methods An electronic search was undertaken to …

Simple Summary Fatigue in older patients has multiple etiologies, as this symptom may be
cancer-related, treatment-related, age-related, or part of frailty syndrome. Physicians need to …