C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative
pathway of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit …

Complement inhibitors have been approved for several immune-mediated diseases and
they are considered the next paradigm-shifting approach in the treatment of …

Thrombotic microangiopathy (TMA) is one of the most devastating sequalae of kidney
transplantation. A number of published articles have covered either de novo or recurrent …

Unique challenges exist in the diagnosis and treatment of glomerular diseases with their
onset during childhood. Mounting evidence supports the notion that earlier onset cases …

Recently, the comprehensive concept of “infection-related glomerulonephritis (IRGN)” has
replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection …

Complement is an evolutionarily conserved system which is important in the defense against
microorganisms and also in the elimination of modified or necrotic elements of the body …

Immunofluorescence studies on paraffin-embedded tissue after Pronase digestion (paraffin
immunofluorescence) is used as a salvage technique in renal pathology, when frozen tissue …

The complement system (CS) has recently been recognized as a bridge between innate and
adaptive immunity that constitutes a very complex mechanism controlling the clearance of …

Haematuria was known as a benign hallmark of some glomerular diseases, but over the last
decade, new evidences pointed its negative implications on kidney disease progression …

Membranoproliferative glomerulonephritis (MPGN) is subdivided into immune-complex-
mediated glomerulonephritis (IC-MPGN) and C3 glomerulopathy (C3G). Classically, MPGN …