Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

Epigenetics play a crucial role in gene regulation and cellular processes. Most importantly,
its dysregulation can contribute to the development of tumors. Epigenetic modifications, such …

Gene expression is regulated by transcription factors that work together to read cis-
regulatory DNA sequences. The 'cis-regulatory code'—how cells interpret DNA sequences …

Arsenic (As) is a metalloid prevalent mainly in soil and water. The presence of As above
permissible levels becomes toxic and detrimental to living organisms, therefore, making it a …

Peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α) regulates
mitochondrial DNA replication and mitochondrial gene expression by interacting with …

Oral cancer is one of the leading causes of death worldwide, with a reported 5-year survival
rate of around 50% after treatment. Epigenetic modifications are considered to have a key …

Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

Abstract Background & Aims Intrahepatic cholangiocarcinoma (ICC) is a devastating liver
cancer with extremely high intra-and inter-tumoral molecular heterogeneity, partly due to its …

Nephrolithiasis is a complicated disease affected by various environmental and genetic
factors. Crystal-cell adhesion is a critical initiation process during kidney stone formation …

Abstract Objectives Systemic sclerosis (SSc) is associated with secondary malignancies.
Previous studies have suggested that mutated cancer proteins, such as RNA polymerase III …