Molecular pathogenesis of ADPKD: The polycystin complex gets complex. Autosomal-
dominant polycystic kidney disease (ADPKD) is one of the most common human monogenic …

Recent studies have highlighted the importance of a parasite protein referred to as the
chloroquine resistance transporter (PfCRT) in the molecular basis of Plasmodium falciparum …

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant
polycystic kidneys. Background The proliferation of mural epithelial cells is a major cause of …

The hypothesis that cell primary cilium is solely responsible for the flow-induced Ca2+
response in MDCK cells was tested by removal of the cilia from mature, responsive cells …

Primary cilia are implicated in the pathogenesis of autosomal-dominant polycystic kidney
disease (ADPKD), which results from defects in polycystin-1 (PC1), but the function of PC1 …

Consider a hypothetical design specification for an integrated communication-control system
within an embryo. It would require short-range (subcellular) and long-range (pan-embryonic) …

Throughout the body there are smooth muscle cells controlling a myriad of tubes and
reservoirs. The cells show enormous diversity and complexity compounded by a plasticity …

In autosomal dominant polycystic kidney disease (ADPKD), arginine vasopressin (AVP)
accelerates cyst growth by stimulating cAMP-dependent ERK activity and epithelial cell …

In polycystic kidney disease (PKD), intracellular cAMP promotes cyst enlargement by
stimulating mural epithelial cell proliferation and transepithelial fluid secretion. The …

Polycystin-1 (PC1), a 4,303-amino acid integral membrane protein of unknown function,
interacts with polycystin-2 (PC2), a 968-amino acid α-type channel subunit. Mutations in …