Background Hypertension is a common comorbidity in patients with unruptured intracranial
aneurysms and is closely associated with the rupture of aneurysms. However, only a few …

OBJECTIVE Although the role of inflammation in the development of aneurysms is
established, less is known about the development of intracranial aneurysms in the setting of …

The Hippo pathway was initially discovered in Drosophila melanogaster and mammals as a
key regulator of tissue growth both in physiological and pathological states. Numerous …

Intracranial aneurysms (IAs) are pathological dilatations affecting cerebral arteries, and their
ruptures lead to devasting intracranial hemorrhages. Although the mechanisms underlying …

Macrophages activation and inflammatory response play crucial roles in intracranial
aneurysm (IA) formation and progression. The outcome of ruptured IA is considerably poor …

Background Recently, the importance of attribute-based medicine has been emphasized.
The effects of early-onset intracranial aneurysms on patients can be significant and long …

It is important to obtain accurate boundary conditions (BCs) in hemodynamic simulations.
This article aimed to improve the accuracy of BCs in computational fluid dynamics (CFD) …

Smooth muscle cells (SMCs) are the major type of cells constituting arterial walls and play a
role to maintain stiffness via producing extracellular matrix. Here, the loss and degenerative …

Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common
genetic condition associated with intracranial aneurysms (IAs). The associated …

Numerous studies have evaluated the effects of hemodynamic parameters on aneurysm
formation. However, the reasons why aneurysms do not initiate in intracranial arteries are …