Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence
play an important role in the regulation of the cell's fate. ROS can cause irreversible damage …

Cardiac development requires coordinated and large-scale rearrangements of the
epigenome. The roles and precise mechanisms through which specific epigenetic modifying …

The role of epigenetics in development has garnered attention in recent years due to their
ability to modulate the embryonic developmental gene expression in response to the …

Epigenetic marks regulate the transcriptomic landscape by facilitating the structural packing
and unwinding of the genome, which is tightly folded inside the nucleus. Lysine-specific …

Histone modifications such as methylation of key lysine residues play an important role in
embryonic development in a variety of organisms such as of Pacific oysters, zebrafish and …

Histone post-translational modifications (PTM) as one of the key epigenetic regulatory
mechanisms that plays critical role in various biological processes, including regulating …

Ticlopidine has inhibitory effects on platelet aggregation via ADP (adenosine diphosphate),
platelet release reaction and depolymerization. In clinical practice, it is commonly used to …