The gut microbiome, ie, the community of bacteria and other microorganisms living in the
human gut, has been implicated both directly and indirectly (mediating the effects of diet) on …

Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …

Background: Large-scale human and mechanistic mouse studies indicate a strong
relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) …

Patients with chronic kidney disease (CKD) have elevated circulating levels of
trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with …

Background Emerging evidence demonstrates that gut dysbiosis is implicated in the
pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving …

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which
increases the risk of renal failure and causes a high global disease burden. Due to the lack …

The gut microbiota plays a pivotal role in the onset and development of diabetes and its
complications. Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite of …

ABSTRACT Background Trimethylamine-N-oxide (TMAO) is a gut microbiota–derived
metabolite produced from dietary nutrients. Many studies have discovered that circulating …

Chronic kidney disease (CKD) is an increasing global health burden. Current treatments for
CKD include therapeutics to target factors that contribute to CKD progression, including …