Membranous nephropathy (MN) occurs due to deposition of immune complexes along the
subepithelial region of glomerular basement membrane. Two previously identified target …

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

The kidneys are frequently targeted by pathogenic immune responses against renal
autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent …

The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

Multiple myeloma is the most frequent monoclonal gammopathy to involve the kidney;
however, a growing number of kidney diseases associated with other monoclonal …

Renal pathologists and nephrologists met on February 20, 2015 to establish an
etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim …

In the past decade, a large body of evidence has accumulated in support of the critical role
of dysregulation of the alternative complement pathway in atypical haemolytic uraemic …

Monoclonal gammopathies are characterized by the overproduction of monoclonal Ig (MIg)
detectable in the serum or urine resulting from a clonal proliferation of plasma cells or B …