C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …

Expansion and acquisition of Th1 cell effector function requires metabolic reprogramming;
however, the signals instructing these adaptations remain poorly defined. Here we found …

Atypical hemolytic and uremic syndrome (aHUS) is a severe disease strongly associated
with genetic abnormalities in the complement alternative pathway. In renal …

Mutations in factor H (CFH), factor I (IF), and membrane cofactor protein (MCP) genes have
been described as risk factors for atypical hemolytic uremic syndrome (aHUS). This study …

Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy caused by
uncontrolled activation of the alternative pathway of complement at the cell surface level that …

Background Pregnancy in women with systemic lupus erythematosus (SLE) or
antiphospholipid antibodies (APL Ab)—autoimmune conditions characterized by …

The implementation of next‐generation sequencing technologies has provided a sharp
picture of the genetic variability in the components and regulators of the alternative pathway …

Background Pregnancy is associated with various forms of thrombotic microangiopathy,
including hemolytic uremic syndrome. A previous small French study suggested that …

After renal transplantation, hemolytic uremic syndrome (HUS) may occur either as a
recurrent or de novo form. Over the past decade, much effort has been devoted to …

CD46 is a complement regulator with important roles related to the immune response. CD46
functions as a pathogen receptor and is a potent costimulator for the induction of interferon-γ …