Diabetes is an emerging global epidemic that affects more that 285 million people
worldwide. Engineering of endocrine pancreas tissue holds great promise for the future of …

Regenerative medicine and stem cell therapy may represent the solution for the treatment of
non-curable human diseases such as type 1 diabetes. In this context of growing demand for …

Fibrin glue (FG) is used in a variety of clinical applications and in the laboratory for localized
and sustained release of factors potentially important for tissue engineering. The aim of this …

Human pluripotent stem cells (hPSCs) have enormous potential to alleviate cell needs for
regenerative medicine, however these cells require expansion in cell colonies to maintain …

Type 1 and type 2 diabetes are caused by a destruction and decrease in the number of
functional insulin‐producing β cells, respectively; therefore, the generation of functional β …

Diabetes is one of the leading causes of death globally. Currently, the donor pancreas is the
only source of human islets, placing extreme constraints on supply. Hence, it is imperative to …

Background Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are gaining
increasing interest as an alternative source of stem cells for regenerative medicine …

Diabetes is a metabolic disease which affects not only glucose metabolism but also lipid and
protein metabolism. It encompasses two major types: type 1 and 2 diabetes. Despite the …

The raising worldwide prevalence of Type 1 and Type 2 diabetes mellitus (T1DM and T2DM)
solicits the derivation of in vitro methods yielding mature and fully functional β-cells to be …

Bioengineering approaches to regulate stem cell fates aim to recapitulate the in vivo
microenvironment. In recent years, manipulating the micro-and nano-scale topography of …