Diabetes mellitus (DM), currently affecting more than 537 million people worldwide is a
chronic disease characterized by impaired glucose metabolism resulting from a defect in …

In vitro differentiation of human pluripotent stem cells (hPSCs) into definitive endoderm (DE)
represents a key step towards somatic cells of lung, liver and pancreas. For future clinical …

A three-dimensional scaffold enables the formation of realistic tissue architecture and
promotes physiological responses to activate the differentiation of induced pluripotent cells …

Background Diabetes and metabolic syndromes are chronic, devastating diseases with
increasing prevalence. Human pluripotent stem cells are gaining popularity in their usage …

Sup. Fig. S2. Growth curve of 4M and 454E2 in definitive endoderm (DE) differentiation.
Adherent or suspension cultured cells were dissociated into single cells using accutase and …

Pluripotent stem cells are promising source of cells for tissue engineering, regenerative
medicine and drug discovery applications. The process of stem cell differentiation is …

Directed differentiation of stem cells plays a vital role in cell replacement therapy. Many
activators and inhibitors targeting different signaling pathways have been identified to …

Background Generation of insulin-producing cells from human pluripotent stem cells
(hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes. Three …

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Introduction: Transplantation of stem cells with a nanofibrous scaffold is a promising …

Pancreatic β‐cells are destroyed by the immune system, in type 1 diabetes (T1D) and are
impaired by glucose insensitivity in type 2 diabetes (T2D). Islet‐cells transplantation is a …