Islets organoids would have value in the cell replacement therapy for diabetes apart from
usual personalized drug screening routes. Generation of a large number of Islets like …

To investigate the effects of the PI3K inhibitors on the differentiation of insulin-producing
cells derived from human embryonic stem cells. Here, we report that human embryonic stem …

Embryonic stem cells (ESCs) are pluripotent stem cells derived from a preimplantation
embryo. ESCs are distinguished by two major properties: their pluripotency (the ability to …

In the multi-step differentiation protocol used to generate pancreatic endocrine cells from
human pluripotent stem cells, the induction of NGN3+ endocrine precursors from the …

In the modern world, type-2 diabetes mellitus has become a leading public healthcare
problem, due to major risks of morbidity and mortality. Prevalence has increased …

Эффективным методом лечения инсулинозависимого сахарного диабета,
альтернативным гормонозаместительной терапии, является трансплантация инсулин …

Spheroids are expected to aid the establishment of an in vitro-based cell culture system that
can realistically reproduce cellular dynamics in vivo. We developed a fluoropolymer scaffold …

Human pluripotent stem cells (PSCs), both embryonic and induced pluripotent stem cells
(iPSCs), have been differentiated into pancreatic β islets in vitro for more than a decade. The …

В настоящее время в мире насчитывается более 350 миллионов больных сахарным
диабетом. По данным Всемирной организации здравоохранения в течение …

Pluripotent stem cells may serve as an alternative source of beta-like cells for replacement
therapy of type 1 diabetes; however, the beta-like cells generated in many differentiation …