Abstract Type I diabetes (T1D) is caused by autoimmune destruction of pancreatic?-cells.
Immediate consequences of T1D are severe weight loss, ketoacidosis and death unless …

Background: Human-induced pluripotent stem cell (iPSC)-derived insulin-producing cells
(IPCs) can be used for islet cell transplantation in type 1 diabetic patients and as patient …

BCL-2 family proteins play an important role in the regulation of cell survival and death.
However, there are also certain members that exhibit tissue-and developmental stage …

Chronic inflammatory diseases are the leading cause of death in the world. One of the
critical steps of inflammation is the recruitment and activation of neutrophils. This process …

Human pluripotent stem cell (hPSC)-derived pancreatic cells are a promising cell source for
regenerative medicine and a platform to study human developmental processes. Stepwise …

Individual cells show variability in their signaling dynamics that often correlates with
phenotypic responses, indicating that cell-to-cell variability is not merely noise but can have …

Pancreatic beta-cell dysfunction is the ultimate cause behind all forms of diabetes. Decades
of research with different animal and cellular models have expanded the knowledge on the …

[cat] La diabetis tipus I és una malaltia autoimmune que resulta de la destrucció de les cèl·
lules β pancreàtiques i es caracteritza per alts nivells de glucosa en sang. El control de la …

ELK1 is a member of the E-twenty-six transcription factor family which is known to be both an
activator and a repressor of transcription and is able to toggle between the two modes. Even …

Pluripotent stem cells (PSCs) derived cardiomyocytes provide an invaluable cell source for
numerous important applications. PSC-cardiomyocytes may be transplanted into injured …