[PDF][PDF] Tranexamic acid: a clinical review
Blood loss and subsequent transfusions are associated with major morbidity and mortality.
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …
Tranexamic acid–an old drug still going strong and making a revival
L Tengborn, M Blombäck, E Berntorp - Thrombosis research, 2015 - Elsevier
Experience with tranexamic acid, an indirect fibrinolytic inhibitor, started as soon as it was
released from Shosuke Okamoto's lab in the early 1960s. It was first prescribed to females …
released from Shosuke Okamoto's lab in the early 1960s. It was first prescribed to females …
Tranexamic acid–associated seizures: causes and treatment
I Lecker, DS Wang, PD Whissell… - Annals of …, 2016 - Wiley Online Library
Antifibrinolytic drugs are routinely used worldwide to reduce the bleeding that results from a
wide range of hemorrhagic conditions. The most commonly used antifibrinolytic drug …
wide range of hemorrhagic conditions. The most commonly used antifibrinolytic drug …
[HTML][HTML] Hemostatic agents for prehospital hemorrhage control: a narrative review
HT Peng - Military Medical Research, 2020 - Springer
Hemorrhage is the leading cause of preventable death in combat trauma and the secondary
cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur …
cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur …
[HTML][HTML] Pharmacokinetics of tranexamic acid after intravenous, intramuscular, and oral routes: a prospective, randomised, crossover trial in healthy volunteers
S Grassin-Delyle, M Semeraro, E Lamy, S Urien… - British Journal of …, 2022 - Elsevier
Background In response to the World Health Organization call for research on alternative
routes for tranexamic acid (TXA) administration in women with postpartum haemorrhage, we …
routes for tranexamic acid (TXA) administration in women with postpartum haemorrhage, we …
Antifibrinolytic therapy and perioperative considerations
JH Levy, A Koster, QJ Quinones, TJ Milling… - Anesthesiology, 2018 - pubs.asahq.org
Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation.
However, after trauma or surgery, excessive fibrinolysis may contribute to coagulopathy …
However, after trauma or surgery, excessive fibrinolysis may contribute to coagulopathy …
Topical tranexamic acid in total knee replacement: a systematic review and meta-analysis
M Panteli, C Papakostidis, Z Dahabreh, PV Giannoudis - The Knee, 2013 - Elsevier
Background To examine the safety and efficacy of topical use of tranexamic acid (TA) in total
knee arthroplasty (TKA). Methods An electronic literature search of PubMed Medline; Ovid …
knee arthroplasty (TKA). Methods An electronic literature search of PubMed Medline; Ovid …
[HTML][HTML] Different dose regimes and administration methods of tranexamic acid in cardiac surgery: a meta-analysis of randomized trials
J Guo, X Gao, Y Ma, H Lv, W Hu, S Zhang, H Ji… - BMC …, 2019 - Springer
Background The efficacy of tranexamic acid (TXA) to reduce perioperative blood loss and
allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but …
allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but …
Exposure–response relationship of tranexamic acid in cardiac surgery: a model-based meta-analysis
PJ Zufferey, J Lanoiselee, B Graouch, B Vieille… - …, 2021 - pubs.asahq.org
Background It is unclear whether high-dose regimens of tranexamic acid in cardiac surgery
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …
[HTML][HTML] Tranexamic acid: current use in obstetrics, major orthopedic, and trauma surgery
Abstract Purpose In this Continuing Professional Development module, we review the
practical pharmacology of tranexamic acid and its clinical use in trauma, obstetrics, and …
practical pharmacology of tranexamic acid and its clinical use in trauma, obstetrics, and …