Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's
initial function was likely that as a free radical scavenger. Melatonin presumably evolved in …

The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Microbial dysbiosis has long been postulated to be associated with the pathogenesis of
inflammatory bowel disease (IBD). Although evidence supporting the anti-colitic effects of …

Atherosclerosis is a leading cause of major vascular events, myocardial infarction, and
ischemic stroke. Tryptophan (TRP) catabolism was recognized as an important player in …

Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The
current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore …

(1) The vicious cycle of innate immune response and reactive oxygen species (ROS)
generation is an important pathological process of osteoarthritis (OA). Melatonin may be a …

Problem Excess caloric intake and irregular circadian rhythm could severely impair female
reproductive, metabolic, and immune function. However, the similarities and differences …

Muscular aging is a complex process and underlying physiological mechanisms are not fully
clear. In recent years, the participation of the NF-kB pathway and the NLRP3 inflammasome …