Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond
Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …
Alzheimer's disease: an updated overview of its genetics
J Andrade-Guerrero, A Santiago-Balmaseda… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …
classified as familial and sporadic. The dominant familial or autosomal presentation …
Multi-omic and multi-view clustering algorithms: review and cancer benchmark
N Rappoport, R Shamir - Nucleic acids research, 2018 - academic.oup.com
Recent high throughput experimental methods have been used to collect large biomedical
omics datasets. Clustering of single omic datasets has proven invaluable for biological and …
omics datasets. Clustering of single omic datasets has proven invaluable for biological and …
Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
Background DNA methylation is one of the main epigenetic mechanisms for the regulation of
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
gene expression in eukaryotes. In the standard model, methylation in gene promoters has …
Epigenetic control of CD8+ T cell differentiation
Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …
Modern epigenetics methods in biological research
Y Li - Methods, 2021 - Elsevier
The definition of epigenetics refers that molecular modifications on DNA that can regulate
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …
[PDF][PDF] DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …
representing the diversity of mouse DNA methylation biology. We present a mouse …
Systematic benchmarking of tools for CpG methylation detection from nanopore sequencing
DNA methylation plays a fundamental role in the control of gene expression and genome
integrity. Although there are multiple tools that enable its detection from Nanopore …
integrity. Although there are multiple tools that enable its detection from Nanopore …
Latest techniques to study DNA methylation
Q Gouil, A Keniry - Essays in biochemistry, 2019 - portlandpress.com
Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has
immensely contributed to our understanding of epigenetic regulation in plants and animals …
immensely contributed to our understanding of epigenetic regulation in plants and animals …
Microarray is an efficient tool for circRNA profiling
S Li, S Teng, J Xu, G Su, Y Zhang, J Zhao… - Briefings in …, 2019 - academic.oup.com
Circular RNAs (circRNAs) are emerging as a new class of endogenous and regulatory
noncoding RNAs in latest years. With the widespread application of RNA sequencing (RNA …
noncoding RNAs in latest years. With the widespread application of RNA sequencing (RNA …