In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …

DNA methylation is a mammalian epigenetic mark that is involved in defining where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

DNA methylation is a mammalian epigenetic mark that participates to define where and
when genes are expressed, both in normal cells and in the context of diseases. Like other …

Highlights•The structure-related regulatory mechanisms of active DNMTs are outlined.•The
therapeutic importance of DNMTs in different cancer types is briefly compared.•The most …

Environmental epigenetics is a rapidly growing field which studies the effects of
environmental factors such as nutrition, stress, and exposure to compounds on epigenetic …

Prostate cancer is one of the most common non-cutaneous malignancies among men
worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or …

ABSTRACT Introduction: DNA methyltransferases (DNMTs), important enzymes involved in
epigenetic regulation of gene expression, represent promising targets in cancer therapy …

DNA hypomethylating drugs that act on DNA methyltransferase (DNMT) isoforms are
promising anticancer agents. By using a well‐characterized live‐cell system to measure …

DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) are important
epigenetic targets during anticancer drug development. Recent study indicates that DNMT …

Abstract The DNMT3A R882H mutation is frequently observed in acute myeloid leukemia
(AML). It is located in the subunit and DNA binding interface of DNMT3A and has been …