Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

[HTML][HTML] AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Screening for abdominal aortic aneurysm: US preventive services task force recommendation statement

DK Owens, KW Davidson, AH Krist, MJ Barry… - Jama, 2019 - jamanetwork.com
Importance An abdominal aortic aneurysm (AAA) is typically defined as aortic enlargement
with a diameter of 3.0 cm or larger. The prevalence of AAA has declined over the past 2 …

Diabetes and aortic aneurysm: current state of the art

J Raffort, F Lareyre, M Clément… - Cardiovascular …, 2018 - academic.oup.com
Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

Association between metformin prescription and growth rates of abdominal aortic aneurysms

J Golledge, J Moxon, J Pinchbeck… - Journal of British …, 2017 - academic.oup.com
Background It has been suggested that diabetes medications, such as metformin, may have
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …

Abdominal aortic aneurysm: evolving controversies and uncertainties

D Carino, TP Sarac, BA Ziganshin… - … Journal of angiology, 2018 - thieme-connect.com
Abdominal aortic aneurysm (AAA) is defined as a permanent dilatation of the abdominal
aorta that exceeds 3 cm. Most AAAs arise in the portion of abdominal aorta distal to the renal …

Diabetes mellitus: is it protective against aneurysm? A narrative review

K Patel, MA Zafar, BA Ziganshin, JA Elefteriades - Cardiology, 2018 - karger.com
Objectives: In the course of extensive clinical aortic surgery, we noticed that the aorta was
quite thick and fibrotic in diabetic patients. We thought the diabetic aortic aorta might be …

[HTML][HTML] Editor's choice–metformin prescription is associated with a reduction in the combined incidence of surgical repair and rupture related mortality in patients with …

J Golledge, DR Morris, J Pinchbeck… - European Journal of …, 2019 - Elsevier
Objectives Currently there is no drug therapy for abdominal aortic aneurysm (AAA) and most
previous investigations have focused on imaging rather than clinical outcomes. The aim of …