Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor
central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is …

Introduction Circadian alterations are prevalent in Alzheimer's disease (AD) and may
contribute to cognitive impairment, behavioral symptoms, and neurodegeneration …

Biological rhythms are pervasive in nature, yet our understanding of the molecular
mechanisms that govern timing is far from complete. The rapidly emerging research focus on …

The circadian-controlled DNA repair exhibits a strong diurnal rhythm. Disruption in circadian
clock and DNA repair is closely linked with hepatocellular carcinoma (HCC) progression, but …

One of the supposed mechanisms that may lead to breast cancer (BC) is an alteration of
circadian gene expression and DNA methylation. We undertook an integrated approach to …

We have been investigating transcriptional regulation of the BMAL1 gene, a critical
component of the mammalian clock system including DNA methylation. Here, a more …

Background: An early symptom of Alzheimer's disease (AD) is a disturbance of the circadian
rhythm that is associated with disrupted sleep/wake cycles. Objective: To investigate if …

Brain‐derived neurotrophic factor (B dnf) regulates neuronal plasticity, slow wave activity
and sleep homeostasis. Environmental stimuli control B dnf expression through epigenetic …

Over the course of evolution, nature has forced organisms under selection pressure to
hardwire an internal time keeping device that defines 24 h of a daily cycle of physiological …