Methionine metabolism in health and cancer: a nexus of diet and precision medicine
Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …
chromatin modification that critically contributes to the regulation of genome integrity …
[PDF][PDF] Gene body methylation can alter gene expression and is a therapeutic target in cancer
DNA methylation in promoters is well known to silence genes and is the presumed
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …
DNA methylation in mammals
E Li, Y Zhang - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …
involved in various biological processes including the silencing of transposable elements …
[PDF][PDF] SETD2 restricts prostate cancer metastasis by integrating EZH2 and AMPK signaling pathways
H Yuan, Y Han, X Wang, N Li, Q Liu, Y Yin, H Wang… - Cancer cell, 2020 - cell.com
The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
S Nouruzi, D Ganguli, N Tabrizian, M Kobelev… - Nature …, 2022 - nature.com
Abstract Treatment with androgen receptor pathway inhibitors (ARPIs) in prostate cancer
leads to the emergence of resistant tumors characterized by lineage plasticity and …
leads to the emergence of resistant tumors characterized by lineage plasticity and …
A decade of exploring the cancer epigenome—biological and translational implications
The past decade has highlighted the central role of epigenetic processes in cancer
causation, progression and treatment. Next-generation sequencing is providing a window …
causation, progression and treatment. Next-generation sequencing is providing a window …
[PDF][PDF] Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
Two recurrent mutations, K27M and G34R/V, within histone variant H3. 3 were recently
identified in∼ 50% of pHGGs. Both mutations define clinically and biologically distinct …
identified in∼ 50% of pHGGs. Both mutations define clinically and biologically distinct …
[HTML][HTML] Interplay between the cancer genome and epigenome
Cancer arises as a consequence of cumulative disruptions to cellular growth control with
Darwinian selection for those heritable changes that provide the greatest clonal advantage …
Darwinian selection for those heritable changes that provide the greatest clonal advantage …
DNA methylation and cancer
M Kulis, M Esteller - Advances in genetics, 2010 - Elsevier
DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …
In normal cells, it assures the proper regulation of gene expression and stable gene …