Purpose Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain
tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In …

Transforming growth factor-β (TGF-β) signaling pathways are well-recognized for their role
in proliferation and epithelial–mesenchymal transition (EMT) of cancer cells, but much less …

Altered gene expression in tumors can be caused by copy number alterations to DNA or
mutation affecting coding or regulatory regions of genes. However, epigenetic events may …

ABSTRACT The Epstein-Barr virus (EBV) predominantly establishes latent infection in B
cells, and the reactivation of the virus from latency is dependent on the expression of the …

Enhancer of zeste homolog 2 (EZH 2) has been characterized as a critical oncogene and a
promising drug target in human malignant tumors. The current EZH 2 inhibitors strongly …

Accumulating evidences indicate that many tumors rely on subpopulations of cancer stem
cells (CSCs) with the ability to propagate malignant clones indefinitely and to produce an …

The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are well-known
xenobiotic-sensing nuclear receptors with overlapping functions. However, there lacks a …

Small interfering RNAs (siRNAs) directed to gene promoters can silence genes at the
transcriptional level. siRNA‐directed transcriptional silencing (RdTS) was first described in …

Malignant pleural mesothelioma (MPM) is a fatal thoracic malignancy, the epigenetics of
which are poorly defined. We performed high-throughput methylation analysis covering …

The myelodysplastic syndromes (MDSs) are a group of diverse and heterogeneous
syndromes characterized by clonal proliferation, bone marrow failure, and an increased risk …