A host of cancer types exhibit aberrant histone modifications. Recently, distinct and recurrent
mutations in a specific histone variant, histone H3. 3, have been implicated in a high …

The histone methylase EZH2 is frequently dysregulated in melanoma and is associated with
DNA methylation and silencing of genes involved in tumor suppression. In this study, we …

Histone methyltransferases (HMTases), as chromatin modifiers, regulate the transcriptomic
landscape in normal development as well in diseases such as cancer. Here, we molecularly …

Carcinogenesis is thought to occur through a combination of mutational and epimutational
events that disrupt key pathways regulating cellular growth and division. The DNA …

Background ETS transcription factors regulate important signaling pathways involved in cell
differentiation and development in many tissues and have emerged as important players in …

CDKN1C (encoding tumor suppressor p57KIP2) is a cyclin-dependent kinase (CDK)
inhibitor whose family members are often transcriptionally downregulated in human cancer …

Human Papillomavirus is the major etiological agent in the development of cervical cancer
but not a sufficient cause. Despite significant research, the underlying mechanisms of …

Pluripotent stem cells evade replicative senescence, whereas other primary cells lose their
proliferation and differentiation potential after a limited number of cell divisions, and this is …

Cancer is a disease that results from the successive accumulation of genetic and epigenetic
alterations. Despite intense study, many unanswered questions about the nature of the …

The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during
early carcinogenesis of lung adenocarcinoma has not been systematically studied. We …