Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …

The character of a cell is defined by its constituent proteins, which are the result of specific
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …

Although it is known that the methylation of DNA in 5′ promoters suppresses gene
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …

Introduction The rapid global rise in metabolic disease suggests that nongenetic
environmental factors contribute to disease risk. Early life represents a window of phenotypic …

CTCF is a ubiquitously expressed regulator of fundamental genomic processes including
transcription, intra-and interchromosomal interactions, and chromatin structure. Because of …

Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …

DNA methylation is a major epigenetic modification of the genome that regulates crucial
aspects of its function. Genomic methylation patterns in somatic differentiated cells are …

▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence
promoters, especially those associated with transposons and imprinted genes. Cytosine …

The biological significance of 5-methylcytosine was in doubt for many years, but is no
longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by …

To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …