In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

Soil salinity is a major environmental stress that restricts the growth and yield of crops.
Understanding the physiological, metabolic, and biochemical responses of plants to salt …

A contribution of DNA methylation to defense against invading nucleic acids and
maintenance of genome integrity is uncontested; however, our understanding of the extent …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

DNA methylation is a conserved epigenetic modification that is important for gene regulation
and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental …

Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the
epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that …

RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA
molecules direct the addition of DNA methylation to specific DNA sequences. The RdDM …

cis-Regulatory elements encode the genomic blueprints that ensure the proper
spatiotemporal patterning of gene expression necessary for appropriate development and …

The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …

Silencing of transposable elements (TEs) is established by small RNA-directed DNA
methylation (RdDM). Maintenance of silencing is then based on a combination of RdDM and …