A low vitamin D status is associated with an increased risk of various cancers, such as of
colon, breast, prostate and hematological cells. The biologically most active vitamin D …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …

Background Nanopore long-read sequencing technology greatly expands the capacity of
long-range, single-molecule DNA-modification detection. A growing number of analytical …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …

Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood
cells with one or more somatic mutations. Individuals with CH are at greater risk for …

Glyphosate is the most widely used herbicide in world agriculture and for general vegetation
control in a wide range of situations. Global and often intensive glyphosate selection of very …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …