Polycomb group proteins and the related histone modification H3K27me3 can maintain the
silencing of key developmental regulators and provide cellular memory. However, how such …

Summary Background Indian Asians, who make up a quarter of the world's population, are
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …

Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

Summary H3K9me3, as a hallmark of heterochromatin, is important for cell-fate specification.
However, it remains unknown how H3K9me3 is reprogrammed during human early embryo …

Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Abstract Purpose of Review Juvenile-onset systemic lupus erythematosus ((j) SLE) is an
autoimmune/inflammatory disease that results in significant damage and disability. When …

Abstract DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian
development. Two isoforms of DNMT3A are differentially expressed from stem cells to …

Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …

Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …