Abstract Vitamin B 12 (B12; also known as cobalamin) is a B vitamin that has an important
role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial …

Protein phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of
brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular …

Background There is growing evidence that Alzheimer disease (AD) is a pervasive
metabolic disorder with dysregulation in multiple biochemical pathways underlying its …

Folate plays a key role in the interactions between nutrition, fetal programming, and
epigenomics. Maternal folate status influences DNA methylation, inheritance of the agouti …

Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …

Background: Increasing evidence points toward the efficacy of nutritional modifications in
delaying cognitive decline and mood/behavioral difficulties in Alzheimer's disease (AD) …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

Cobalamin (Cbl), also known as vitamin B12, is an indispensable water-soluble molecule.
As far as it is known at present, its function is restricted to cofactorial activity for only two …

ABSTRACT The Presenilin1 (PSEN1) gene encodes the catalytic peptide of the γ-secretase
complex, a key enzyme that cleaves the amyloid-β protein precursor (AβPP), to generate the …

Peripheral biomarkers play an indispensable role in quick and reliable diagnoses of any
kind of disease. With the population ageing, the number of people suffering from age-related …