Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

[HTML][HTML] Practical considerations for choosing a mouse model of Alzheimer's disease

JL Jankowsky, H Zheng - Molecular neurodegeneration, 2017 - Springer
Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …

[HTML][HTML] AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Abdominal aortic aneurysms

N Sakalihasan, JB Michel, A Katsargyris… - Nature reviews Disease …, 2018 - nature.com
An abdominal aortic aneurysm (AAA) is a localized dilatation of the infrarenal aorta. AAA is a
multifactorial disease, and genetic and environmental factors play a part; smoking, male sex …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

[HTML][HTML] PCSK9, a novel immune and ferroptosis related gene in abdominal aortic aneurysm neck

J Zhuang, H Zhu, Z Cheng, X Hu, X Yu, J Li, H Liu… - Scientific Reports, 2023 - nature.com
The gene expression profile of abdominal aortic aneurysm (AAA) neck is not fully
understood. The etiology of AAA is considered to be related to atherosclerosis and the …

Association between metformin prescription and growth rates of abdominal aortic aneurysms

J Golledge, J Moxon, J Pinchbeck… - Journal of British …, 2017 - academic.oup.com
Background It has been suggested that diabetes medications, such as metformin, may have
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …

[HTML][HTML] Metformin prescription status and abdominal aortic aneurysm disease progression in the US veteran population

NK Itoga, KA Rothenberg, P Suarez, TV Ho… - Journal of vascular …, 2019 - Elsevier
Background Identification of a safe and effective medical therapy for abdominal aortic
aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort …

[HTML][HTML] MicroRNA-19b-3p dysfunction of mesenchymal stem cell-derived exosomes from patients with abdominal aortic aneurysm impairs therapeutic efficacy

Y Zhang, X Huang, T Sun, L Shi, B Liu, Y Hong… - Journal of …, 2023 - Springer
Senescence of vascular smooth muscle cells (VSMCs) contributes to the formation of
abdominal aortic aneurysm (AAA). Although mesenchymal stem cell exosomes (MSC-EXO) …

Mouse models for abdominal aortic aneurysm

J Golledge, SM Krishna, Y Wang - British Journal of …, 2022 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year.
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …