Objective: ADAM (a disintegrin and metalloproteinase) 15—a membrane-bound
metalloprotease from the ADAM (disintegrin and metalloproteinase) family—has been linked …

Background Prior studies have suggested aortic peak wall stress (PWS) and peak wall
rupture index (PWRI) can estimate the rupture risk of an abdominal aortic aneurysm (AAA) …

Pentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has
significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent …

Abdominal aortic aneurysm (AAA) is an often deadly disease without medical, non-invasive
treatment options. The upregulation of vascular cell adhesion molecule-1 (VCAM-1) on …

Background and aims Abdominal aortic aneurysm (AAA) is a common disease; however, its
exact pathogenesis remains unknown, and no specific medical therapies are available …

Objective Rivaroxaban is a specific factor Xa (FXa) inhibitor for venous thromboembolism
treatment. Recently, increasing evidence have reported the beneficial effects of rivaroxaban …

Background: Abdominal aortic aneurysm (AAA), a common disease involving the segmental
expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA …

Background Multiple observational studies have associated metformin prescription with
reduced progression of abdominal aortic aneurysm (AAA). The Metformin Aneurysm Trial …

Background The protective effects of polyamines on cardiovascular disease have been
demonstrated in many studies. However, the roles of spermidine, a natural polyamine, in …

Background and aims Inflammation, oxidative stress, matrix degradation, medial calcification
and vascular smooth muscle cell (VSMC) loss are prominent features in abdominal aortic …