Spermidine suppresses development of experimental abdominal aortic aneurysms

S Liu, T Huang, R Liu, H Cai, B Pan… - Journal of the …, 2020 - Am Heart Assoc
Background The protective effects of polyamines on cardiovascular disease have been
demonstrated in many studies. However, the roles of spermidine, a natural polyamine, in …

Effect of blood pressure lowering drugs and antibiotics on abdominal aortic aneurysm growth: a systematic review and meta-analysis

J Golledge, TP Singh - Heart, 2021 - heart.bmj.com
Objective There is currently no medical treatment proven to limit abdominal aortic aneurysm
(AAA) progression. The aim of this systematic review and meta-analysis was to pool data …

Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections

YH Shen, SA LeMaire - Current problems in surgery, 2017 - Elsevier
The aorta is the largest artery and can be divided into several segments (Fig 1). The
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …

[HTML][HTML] Pharmacological inhibition of cathepsin S suppresses abdominal aortic aneurysm in mice

CH Lai, JY Chang, KC Wang, FT Lee, HL Wu… - European Journal of …, 2020 - Elsevier
Objective Evidence suggests that cathepsin S (CTSS), a potent mammalian elastase,
participates in abdominal aortic aneurysm (AAA) formation. This study examines the …

The reproducibility of measuring maximum abdominal aortic aneurysm diameter from ultrasound images

EO Matthews, J Pinchbeck, K Elmore, RE Jones… - The Ultrasound …, 2021 - Springer
Background Accurate repeat assessment of the diameter of an abdominal aortic aneurysm
(AAA) is important. This study investigated the reproducibility of different methods of …

Relationship between metformin and abdominal aortic aneurysm

J Raffort, R Hassen-Khodja, E Jean-Baptiste… - Journal of vascular …, 2020 - Elsevier
Abdominal aortic aneurysm (AAA) is a life-threatening disease and pharmacologic agents to
treat the disease remain lacking for clinical practice. Epidemiologic studies have highlighted …

Association between aortic peak wall stress and rupture index with abdominal aortic aneurysm–related events

TP Singh, JV Moxon, TC Gasser, J Jenkins… - European …, 2023 - Springer
Objective The aim of this study was to assess whether aortic peak wall stress (PWS) and
peak wall rupture index (PWRI) were associated with the risk of abdominal aortic aneurysm …

Comparison of peak wall stress and peak wall rupture index in ruptured and asymptomatic intact abdominal aortic aneurysms

TP Singh, JV Moxon, V Iyer, TC Gasser… - British Journal of …, 2021 - academic.oup.com
Background Previous studies have suggested that finite element analysis (FEA) can
estimate the rupture risk of an abdominal aortic aneurysm (AAA); however, the value of …

[HTML][HTML] Systematic review and meta-analysis of the association between intraluminal thrombus volume and abdominal aortic aneurysm rupture

TP Singh, SA Wong, JV Moxon, TC Gasser… - Journal of vascular …, 2019 - Elsevier
Background Intraluminal thrombus (ILT) is present in most abdominal aortic aneurysms
(AAAs), although its role in AAA progression is controversial. Methods A literature search …

[HTML][HTML] Athero-occlusive disease appears to be associated with slower abdominal aortic aneurysm growth: an exploratory analysis of the TEDY trial

EO Matthews, JV Moxon, TP Singh… - European Journal of …, 2022 - Elsevier
Objective The role of atherosclerosis in abdominal aortic aneurysm (AAA) pathogenesis is
controversial. The aim of this study was to compare AAA growth in patients who did and did …