A novel hybrid drug delivery system for treatment of aortic aneurysms

K Yoshimura, H Aoki, C Teruyama, M Iijima… - International Journal of …, 2020 - mdpi.com
Ongoing aortic wall degeneration and subsequent aneurysm exclusion failure are major
concerns after an endovascular aneurysm repair with a stent-graft. An ideal solution would …

Aortic aneurysms and dissections series: part II: dynamic signaling responses in aortic aneurysms and dissections

YH Shen, SA LeMaire, NR Webb… - … , and vascular biology, 2020 - Am Heart Assoc
Aortic structure and function are controlled by the coordinated actions of different aortic cells
and the extracellular matrix. Several pathways have been identified that control the aortic …

Photocrosslinking of adventitial collagen in the porcine abdominal aorta: a preliminary approach to a strategy for prevention of aneurysmal rupture

TV Chirila, S Suzuki - Designs, 2022 - mdpi.com
This study was aimed at generating data for designing a potential method to prevent the
rupture of the abdominal aortic aneurysm (AAA). We found that the mechanical strength and …

Recombinant Interleukin‐19 suppresses the formation and progression of experimental abdominal aortic aneurysms

H Tanaka, B Xu, H Xuan, Y Ge, Y Wang… - Journal of the …, 2021 - Am Heart Assoc
Background Interleukin‐19 is an immunosuppressive cytokine produced by immune and
nonimmune cells, but its role in abdominal aortic aneurysm (AAA) pathogenesis is not …

Inhibition of phosphatidylinositol 3-kinease suppresses formation and progression of experimental abdominal aortic aneurysms

J Yu, R Liu, J Huang, L Wang, W Wang - Scientific Reports, 2017 - nature.com
Accumulating evidence suggests an important role of Phosphatidylinositol 3-kinease (PI3K)
pathway in inflammatory cells infiltration. Given the essential role of inflammatory cells …

High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II …

SM Krishna, SW Seto, R Jose, J Li, J Moxon… - Clinical …, 2017 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized
by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene …

[HTML][HTML] Effect of telmisartan on the peak wall stress and peak wall rupture index of small abdominal aortic aneurysms: an exploratory analysis of the TEDY trial

TP Singh, JV Moxon, TC Gasser, RL Dalman… - European Journal of …, 2022 - Elsevier
Objective This study was an unplanned exploratory analysis of a subset of participants from
the Telmisartan in the Management of Abdominal Aortic Aneurysm (TEDY) trial. It aimed to …

Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development

CE Fernandez-García, C Tarin… - Clinical …, 2017 - portlandpress.com
Abdominal aortic aneurysm (AAA) evolution is unpredictable and no specific treatment exists
for AAA, except surgery to prevent aortic rupture. Galectin-3 has been previously associated …

Decision tree based classification of abdominal aortic aneurysms using geometry quantification measures

SA Parikh, R Gomez, M Thirugnanasambandam… - Annals of biomedical …, 2018 - Springer
Abdominal aortic aneurysm (AAA) is an asymptomatic aortic disease with a survival rate of
20% after rupture. It is a vascular degenerative condition different from occlusive arterial …

Systematic review examining the association of angiotensin converting enzyme inhibitor and angiotensin receptor blocker prescription with abdominal aortic …

K Tian, S Thanigaimani, K Gibson… - European Journal of …, 2024 - Elsevier
Objective Whether angiotensin II blockade is an effective medical treatment for abdominal
aortic aneurysms (AAAs) has not been established. This systematic review and meta …