Systematic review and meta-analysis of interventions to slow progression of abdominal aortic aneurysm in mouse models

J Phie, S Thanigaimani, J Golledge - … , Thrombosis, and Vascular …, 2021 - Am Heart Assoc
Objective: There are no current effective abdominal aortic aneurysm (AAA) drug therapies.
An important limitation of most preclinical studies is that they test the effect of drugs on AAA …

[HTML][HTML] Fucoidan attenuates angiotensin II-induced abdominal aortic aneurysms through the inhibition of c-Jun N-terminal kinase and nuclear factor κB activation

SH Tsai, JC Wang, WI Liao, YJ Hsu, CY Lin… - Journal of Vascular …, 2018 - Elsevier
Background Rupture of abdominal aortic aneurysm (AAA) is one of the leading causes of
sudden death among the elderly. Most incidental AAAs are below the threshold for …

Activated invariant natural killer T cells infiltrate aortic tissue as key participants in abdominal aortic aneurysm pathology

T Miao, T Wang, T Feng, D Yuan, Q Guo, F Xiong… - …, 2021 - Wiley Online Library
Adaptive immunity and innate immunity have been implicated in the pathogenesis of
abdominal aortic aneurysm (AAA), and damage and remodelling in the tunica media are a …

Photobiomodulation and estrogen stabilize mitochondrial membrane potential in angiotensin–II challenged porcine aortic smooth muscle cells

L Gavish, D Gilon, R Beeri, A Zuckerman… - Journal of …, 2021 - Wiley Online Library
Rupture of Abdominal aortic aneurysm (AAA) is among the 15 leading causes of death after
age 65. Using high frequency ultrasound, we showed that photobiomodulation (PBM) …

Aortic to caudal vena cava ratio measurements using abdominal ultrasound are increased in dogs with confirmed systemic hypertension

M Holland, J Hudson, Y Bao… - Veterinary Radiology & …, 2020 - Wiley Online Library
Chronically sustained systemic hypertension in dogs can damage the kidneys, eye, brain,
heart, and vessels. In human medicine, systemic hypertension has been implicated as the …

MicroRNA‐29a‐3p regulates abdominal aortic aneurysm development and progression via direct interaction with PTEN

Y Zhou, M Wang, J Zhang, P Xu… - Journal of Cellular …, 2020 - Wiley Online Library
Various research studies have been conducted in deducing the role of microRNAs
(miRNAs) in the pathogenesis and physiological processes of various systematic diseases …

[HTML][HTML] Aortic and systemic arterial stiffness responses to acute exercise in patients with small abdominal aortic aneurysms

M Perissiou, TG Bailey, M Windsor, K Greaves… - European Journal of …, 2019 - Elsevier
Objective/background Elevated arterial stiffness is a characteristic of abdominal aortic
aneurysm (AAA), and is associated with AAA growth and cardiovascular mortality. A bout of …

Top 10 candidate aortic disease trials

RL Dalman, A Wanhainen, K Mani… - Journal of Internal …, 2020 - Wiley Online Library
Aortic pathologies such as aneurysm, dissection and trauma are relatively common and
potentially fatal diseases. Over the past two decades, we have experienced unprecedented …

Glucagon-Like Peptide-1 Inhibits the Progression of Abdominal Aortic Aneurysm in Mice: The Earlier, the Better

X Zhao, Z Cheng, H Zhang, Y Guo, L Zhao… - … Drugs and Therapy, 2023 - Springer
Abstract Objectives Glucagon-like peptide-1 (GLP-1) has a cardiovascular protective effect
by preventing abdominal aortic aneurysm (AAA) formation. However, it is unclear at what …

[HTML][HTML] Abdominal aortic aneurysm: natural history, pathophysiology and translational perspectives

G Accarino, AN Giordano, M Falcone… - Translational …, 2022 - ncbi.nlm.nih.gov
An abdominal aortic aneurysm (AAA) is a degenerative pathology that affects the infrarenal
segment of the aorta, leading to its progressive dilatation and eventually rupture. The …