Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct
properties and diverse cellular functions, which is being explored at a steadily increasing …

Breast cancer (BC) is the most frequently occurring malignancy in women worldwide.
Despite the substantial advancement in understanding the molecular mechanisms and …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
which is characterized by the lack of clinically significant expression of estrogen receptor …

Cells of a multicellular organism are genetically homogeneous but structurally and
functionally heterogeneous owing to the differential expression of genes. Many of these …

Abnormal epigenetic regulation has been implicated in oncogenesis. We report here the
identification of somatic mutations by exome sequencing in acute monocytic leukemia, the …

Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …

Acute myeloid leukemia (AML) arises within the bone marrow from a malignant
hematopoietic progenitor cell. Though AML is still often fatal, cure rates overall continue to …

Carcinogenesis involves the chemical and structural alteration of biomolecules in cells.
Aberrant methylation of DNA is a well-known carcinogenic mechanism and a common …

The anti-skin carcinogenic effects of green tea catechins have been studied extensively in
vitro and in vivo models but the precise epigenetic molecular mechanisms are still unclear …

The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and
plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family …