Autosomal dominant polycystic kidney disease is one of the most common hereditary
disorders, being 10 times more common than sickle cell disease, 15 times more common …

Discussion DR. F. GARY TOBACK (Department of Medicine and Cell Physiology, and
Professor of Medicine and Cell Physiology, University of Chicago, Chicago, Illinois): This …

PKD1 and PKD2 are two recently identified genes that are responsible for the vast majority
of autosomal polycystic kidney disease, a common inherited disease that causes …

It is not known whether mutations in the PKD1 gene cause autosomal dominant polycystic
kidney disease (PKD) by an activating (gain-of-function) or an inactivating (loss-of-function) …

As a nephrologist thinks about the renal cystic diseases, several observations emerge: first,
the disorders are numerous and vari-able in etiology; second, they span a wide range of …

Polycystic kidney disease: Primary extracellular matrix abnormality or defective cellular
differentiation? Polycystic kidney disease (PKD) is inherited as a dominant or recessive trait …

Novel therapies in autosomal dominant polycystic kidney disease (ADPKD) signal the need
for markers of disease progression or response to therapy. This study aimed to identify …

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited renal
disease characterized by many fluid‐filled cysts and interstitial fibrosis in the kidneys …

Extracellular vesicles are a diverse group of particles that include exosomes, microvesicles,
and apoptotic bodies and are defined by size, composition, site of origin, and density. They …

Autosomal dominant polycystic kidney disease, the most common monogenetic disorder, is
characterized by gradual replacement of normal renal parenchyma by fluid-filled cysts …